The Protocol Concerning Pollution from Land-Based Sources and Activities (LBS Protocol) to the Cartagena Convention was adopted in Oranjestad, Aruba, on 6 October 1999. 

The Protocol is the most significant agreement of its kind. It includes regional effluent limitations for domestic wastewater (sewage) and requires the development of plans to address agricultural non-point sources of pollution. Specific schedules for implementation are also included in the Protocol.

The Protocol entered into force on August 13, 2010. The GEF CReW+ project has been supporting the adoption and ratification of the LBS protocol,  8 participating countries of the project have ratified it.